Endocrine Abstracts

Introduction: GLP-1 receptors have been fund on different types of neoplasm’ cells and density of these receptors appears to be more frequent in some of them. GLP-1 receptor scanning offers a new approach for successful localization of small or not detectable by other methods insulinomas and other cancers such as MTC, gastrinoma, pheochromocytoma, gastrinoma, etc.Aim of the study: The aim of study was to present first successful experiences with the...

Introduction: Amiodarone a potent antiarrhythmic medication induces thyroid dysfunction in about 20% of patients. Amiodarone-induced hypothyroidism (AIH) usually occurs early in the course of treatment, more often in iodine-sufficient areas, in women, and in the presence of thyroid autoantibodies. Long-term treatment with amiodarone is associated with a reduction in prevalence of AIH, which may reflect adaptation of the thyroid autoregulatory mechanisms to iodine excess.<p...

Amiodarone is a widely used antiarhrythmic agent. Although life-threatening side effects of amiodarone therapy are well known, it’s not always possible to replace it with dronedarone. Some clinical trials showed that treatment with dronedarone led to significantly more unfavourable end-points (e.g. in congestive heart failure). Therapy of amiodarone induced thyrotoxicosis still raises many questions concerning optimal treatment choice to achieve euthyreosis as soon as pos...

Introduction: Pheochromocytoma is a tumour of chromaffin cells of the sympathetic nervous system and its clinical symptoms are associated with excessive production and release of catecholamines.Case report: We report a rare case of non-functioning malignant adrenal oncocytic pheochromocytoma incidentally found during yearly repeated ultrasound abdomen examination in a 78-year-old man with history of cardiovascular diseases: aortal abdominal aneurysm, isc...

Objective: To determine the progression rate to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes (DM2) in normal glucose tolerant (NGT) people during 8 years follow up using WHO 1999 criteria and new criteria (IFG-fasting glucose 5.6–6.9 mmol/l).Research design and methods: This is an eight year prospective study in a randomly selected urban population aged >=40 years living in Krakow, Poland. 1752 persons had NGT.b...

Introduction: Among three types of gastric neuroendocrine tumors (GEPNETV) type 1 are most common. At the basis of the pathogenesis of type 1 is atrophic gastritis, which leads to achlorhydria and deficiency of intrinsic factor, resulting in G cell hyperplasia and hypergastrinaemia. Gastric endoscopy usually reveals the multiple and polypoid lesions (<1–2 cm) in the corpus. Five-year survival in these patients is not different from survival in the selected age group p...

Differentiated thyroid cancer (DTC) is more frequent in women than in men.The aim of the study was to analyze whether factors connected with the female sex could increase the risk of DTC.Material and methods: Ninety nine patients with a mean age±S.D. of 40.5±5.9 years with DTC and 51 healthy women with a mean age of 36.52±8.3 years were examined. Gynecological and obstetric histories were taken and ser...

Objective: To determine the predictive risk factors for the development of type 2 diabetes mellitus (DM) in patients with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) during the 8.5 follow up.Research design and methods: This is an 8-year prospective study in a randomly selected urban population including 2838 subjects aged ≥40 years living in Krakow. Seven hundred and six had IGT (387) or IFG (319) based on WHO criteria and 2...

Introduction and aim: MTC accounts for 5–10% of all thyroid cancers. Because of elevation postoperative calcitonin, short doubling time of calcitonin and no disease in available imaging techniques in some MTC patients, searching for new targets for radioisotope diagnostics is necessary.Among other overexpression of GLP-1 receptors have been shown on parafollicular thyroid C-cells.The aim of this study was to present the first ...

Background: Type 3 neuroendocrine tumors of the stomach (type 3 NETV) are very rare subtypes of NETV with poor prognosis, not fully understood biology and not well investigated diagnostic and therapeutic procedures. The aim of the study was to analyze tumor biology and the outcome of differentiated treatment in patients with type 3 neuroendocrine tumors of the stomach.Methods: A prospective 10 years follow up of five patients with type 3 NETV treated in ...